Not really. Yeah, it can get tiresome, but the look on their faces after it's done is always worth it.
My Mom gets mad at me. She keeps telling me that as one gets older, one's religion gets stronger. I just get more militant. I was with a Catholic woman for 4+ years, and it didn't work out in ways I've described elsewhere. With all of eternity and all of the universe supposedly at their fingertips, the world I entered by being with her was so so so so small, and I was always treated like an intruding stranger. She asked me near the end if I thought there was a historical Jesus. I said I didn't know, but it didn't matter to me. Because we have Roman law codes from the time, there was no tomb to be full or empty. She got mad. I showed her a Bart Ehrman lecture where he discussed the different goals of the different gospels. She got mad.
No I don't get frustrated because I don't get into debate mode with them. The conversations with my "god" friends/ co-workers/ acquaintances are mostly based on me listening and trying to assess just how deeply into their particular delusion. I don't want to have unnecessary conflict with anyone really.. so I find it helpful to know what buttons exist for them to be pushed and then do my best to avoid pushing them. That said.. I don't spend any significant amount of time "hanging out" with "god"folk.