Making predictions, especially in politics in America, is not easy, but the Democrats have a couple of advantages in the Senate this election because of timing.
There are 14 Democratic seats defending -- 10 likely safe -- 4 in play.
There are 20 Republican seats defending -- 14 likely safe -- 6 in play.
That means that
Democrats have 36 not running + 10 likely safe = 46 likely seats => 4 in play
Republicans have 30 not running + 14 likely safe = 44 likely seats => 6 in play

Democrats can win the Senate in 2022 -- and make it Manchin-proof -- [rawstory.com]

Republicans were predicted to dominate redistricting — but all that has changed in the past few days -- [rawstory.com]

The House will be interesting.