[jlar.rovedar.com]
The Anticancer Potential of Ivermectin: Mechanisms of Action and Therapeutic
Implications
Ivermectin is a well-known antiparasitic drug inthe macrolide class with a 16-membered ring. Its use in treatingvarious parasitic diseases, including onchocerciasis, lymphatic filariasis, and strongyloidiasis, is well established. The present study aimed to review the mechanisms of action and therapeutic implicationsof Ivermectin as an anticancer agent.Recently, the potential use of ivermectin in cancer treatment has emerged. A growing body of evidence suggests that ivermectin has anticancer properties, makingit an attractive candidate for treatingvarious types of cancer.Studies have shown that ivermectin targets multiple signaling pathways, including the Wnt/β-catenin, PI3K/Akt/mTOR, and STAT3 pathways, to inhibit cancer cell proliferation and induce apoptosis. Inhibition of these pathways by ivermectin leads to suppressionof cancer cell growth, making it an effective antitumor agent. Additionally, ivermectin has been shown to induce autophagy, which can lead to programmed cell death in cancer cells.