Not sure about psychedelics but this does bring to mind a study that explored near death experience. Some found god, others lost god.

Long time ago my experiences with psycadelics was always good, never overwhelming. Mushrooms are best but a few times people got something that made them ill. I always had a contentment hangover after eating mushrooms.

I may have been taken psycadelics a couple of dozen times, forty years ago.

I’ve eaten a lot of acid, I’d say probably between 1 and 2 sheets. I abruptly stopped taking it when I was 18 or 19 because I didn’t need it anymore. I used it to better “see reality”, and I just no longer need it. With that said, I still wouldn’t mind tripping now, over 20 years later. Maybe the next time I’m in Cali we can trip. At least some of us

I think most persons who go that road do so wanting to experience a feeling of release and to connect with something other than the Sunday Service. Native Indians had a beautiful way of life and understanding thier existence which for the most part was totally in balance and harmony with Mother Earth, and Nature. Even the Ancients Greeks and had a more plausible explaination of life than what we are told 'to believe'. They were also advanced in Mathematics and other sciences which are still in existence today. What drugs did they take? I'm sure they had some and that the natural ones are still available because they are natural.

Can't say I've ever had any kind of "spiritual" experience while using psychedelics.
Everyone is different, but I can't imagine anyone having any experience that would make them become more or less anything, simply from taking acid (or anything else).
It might amplify whatever issues one may already be (or have been) having, but I kind of doubt it would create an issue if one didn't already exist.

[psychologytoday.com]