Sam Harris's Waking Up podcast
The Joe Rogan experience podcast both are IMO pretty interesting.

Not necessarily science/comedy, but these are in my regular lineup for my 2 - 2 1/2 hours on the road every day.

Code Switch (Race, identity)
Dear Sugars
Death, Sex & Money
Love + Radio
Make Me Smart with Kai Ryssdal and Mollie
The Moth
Planet Money
Relationship Alive (sometimes)
S-Town! (I admit, I didn't like the ending, but good story.)
Serial - Season 1
Terrible, Thanks for Asking
This American Life
This is Actually Happening
Wait Wait Don't Tell Me
Waking Up - Sam Harris (science and philosophy)

What are some of your favorites @carcmcgarc?

The Skeptics Guide to the Universe and The Geologic Podcast

The thinking atheist

Dan Carlin's Hardcore History (No, it is not porn!) Speculation and commentary on history. If Dan had have been my high school history teacher, I would not have skipped class!

[dancarlin.com]

Dan Carlin's "Common Sense" podcast is a Political Commentary podcast by a self-described "political martian." It is neither Right nor Left.

[dancarlin.com]

Tangentially Speaking, Infinite Monkey Cage, Hardcore History, Revisionist History, Savage Love

Sorry, no true crime. Mostly news and comedy:
Counterspin
WTF
The Frame
The Gist
Fresh Air
Here's the Thing
Le Show
WWDTM
Zappacast

10@10 - with Dave Morey!

I forgot about this one.

Iroquois History & Legends Podcast.

[longhousepodcast.com]

Bill Burr's Monday morning podcast
Joe Rogan's podcast
Your Mom's house
Razor on Los Anarchy ( mine)

'Real Time' and 'Left, Right and Center'

The only pod casts i made a point of listening to is "Wait Wait Don't Tell Me" the NPR news quiz show. My next favorite woudl probably be "The TED Radio Hour", which is also an NPR show.

Welcome to Night Vale. And I've seen them live twice. Cecil is amazing.

"Great lives" BBC iPlayer radio 4 & many of the other ones mentioned. I ditched TV 5 years ago and have filled that space with quiet, reading, radio & podcasts ??

PC Perspective
The WAN Show
Awesome Hardware
There George Rockall-Schmidt Show
Caravan of Garbage
Rich Roll
Startalk Radio

IoT podcast, Talking headways, Plantery radio, The thinking Atheist, Star Talk,Friendly Atheist

I've listened to The Infinite Monkey Cage from BBC Radio 4 for many years with physicist Brian Cox and comedian Robin Ince. There's so many episodes that now I can go back and rehear shows without feeling slighted.

The F Plus, The Dollop... I'm sure there are more, these are just the ones that come to mind.

The Godawful movies podcast is hilarious, love those guys.