In January 1910, Samuel Clemens traveled to Bermuda for his health, but heart trouble drove him home again. He died on April 21, 1910, at age 74, in his final home in Redding, Connecticut. His body was dressed in one of his signature white suits and ultimately taken to Elmira, New York – Olivia Clemens’s hometown and always a second home for the Clemens family. There he was laid to rest next to his wife and children.
In his last substantial manuscript, "Letters from the Earth," Clemens wrote: “Life was not a valuable gift, but death was. Life was a fever-dream made up of joys embittered by sorrows, pleasure poisoned by pain; a dream that was a nightmare-confusion of spasmodic and fleeting delights, ecstasies, exultations, happinesses, interspersed with long-drawn miseries, griefs, perils, horrors, disappointments, defeats, humiliations, and despairs – the heaviest curse devisable by divine ingenuity; but death was sweet, death was gentle, death was kind; death healed the bruised spirit and the broken heart, and gave them rest and forgetfulness; death was man's best friend; when man could endure life no longer, death came and set him free.”
Source: The Mark Twain House & Museum
He was truly great, but that was a really depressing sentiment, words of grieving, by the sound of them.
He lost a child and his wife, among others, so had a lot of pain (as most humans do).