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95% Efficacy Rate in Stage II Clinical Trials!

Go Pfizer!!

[sciencemag.org]

TheoryNumber3 8 Nov 18
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6 comments

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Can't we all just be encouraged about the fact that they're finding various possible solutions? I am

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The Pfizer and Moderna vaccines require sub zero storage. If they warm up a little the are useless. This will be a great problem. On the other hand the Johnson and Johnson vaccine which will soon be ready, only requires regular refrigeration. I think this vaccine will be the one Americans will use in the future.

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I'm keeping my excitement tempered on this one as well as the Moderna model. What no one seems to be mentioning is that both of these vaccine development methods are brand spanking new. Not new to research, but we've not ever had an mRNA based vaccine make it through clinical trials until possibly now, and suddenly we have 2? Efficacy is one thing. Safety is another. Most phase 3 trials last on average 3 years. Phase 3 trials are conducted to confirm and expand on safety and effectiveness results from Phase 1 and 2 trials, to compare the drug to standard therapies for the disease or condition being studied, and to evaluate the overall risks and benefits of the drug. I realize emergency use doesn't follow the same time line, but damn, this is fast. Quite possibly too fast.

You're obviously in the medical or pharma field. I defer to your knowledge 🙂

Obviously it's a race for profits, so they're pulling out all the stops, but as you said, I hope they don't substitute speed for safety. That's a pretty big plum someone is going to win

@TheoryNumber3 Don't get me wrong, I'm as hopeful as anyone that this becomes a game changer. Even moreso considering it would be developing an entirely new class of vaccines that could potentially be made to work against other infectious diseases down the road, but yes, I wish the scientific data had come out before the PR marketing announcement. I read yesterday that the FDA's requirement for emergency use approval in this situation is a mere 2 months of follow up safety data on only half the study participants. Now if we were talking about an old school class of vaccines, this wouldn't bother me so much, because we well know the safety of those mechanisms. If they have really developed a safe and effective vaccine using mRNA, that's huge scientific news even outside of Covid-19 applications. Maybe they don't want to scare people off of it being a new technique and so are downplaying it? I don't know. I just know it furrows my brow a bit and I'm eager to see the actual studies and the peer review response. I am a Healthcare worker, currently in a hospital becoming fast overwhelmed with Covid-19 patients, but most of my knowledge on this subject comes from a decade of working with cancer patients on clinical trials and a personal passion/fascination with infectious diseases, especially emerging ones. Fingers, toes and eyes crossed hoping these new vaccines are as good as they 'sound' from the PR reports. 😊

@Amzungu What would we do without you guys. Thank you so much. Your work has to be an exhausting effort.

I'm with you. I hope they're right, but I agree it's worrisome that they are fast-tracking it but under the circumstances, with people dying in such large numbers, what can they do? However, as you said, it's impossible to know the long range implications when the testing period is so short.

Let's all cross our fingers and hope one of them works.

@TheoryNumber3 I couldn't agree more. Also, all that I've said, barring any major red flags, I'll happily jump in line for my free shot from my employer. One way or another, we need to figure this shit out, and it will take participation to get there. The essential science is sound, and we can hope this may be a turning point in our ability to get a grip on Covid-19 as well as an avenue to continue the fight in the future. Wouldn't it be great if something so positive could come from this wreck of a year? I'm an ever optimistic skeptic. 😉

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Yeah

bobwjr Level 10 Nov 18, 2020
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There are two other companies achieving the same rate with vaccines that require far less intensive cold to preserve and distribute.

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They come out with this the day after Moderna releases figures of 94.5'% efficacy. Their vaccine still requires storage at -95°F putting it at a disadvantage with other more stable vaccine programs

Ohferpetessake, my brother transports organs world-wide in $10 coolers with dry ice....hardly insurmountable

@AnneWimsey To 100 million people? Moderna's vaccine is stable and has 94.5% efficacy (allegedly). Curious that Pfizer would announce a figure of 95% the day after Moderna. Tweaking the stock? Just saying.

@barjoe refrigerated/freezer trucks/boxcars/ cargo ships right now just sitting there, plenty of dry ice to be had.....if they can distribute ice cream, they can distribute other frozen things.

@AnneWimsey They will sell all their vaccine. There's going to be 10 different vaccines. Some of them are more stable. When the vaccine is available you won't be able to pick and choose. You'll take whatever Covid shot they give you. If they are approved they'll all be fine.

@barjoe you have never seen the catchy commercials for "whatever" miracle cure, followed in about 18 months with lawyers trolling for class-action members who have been harmed? You can take what they give you, I will stand back & observe for Quite some time, thanks....

@AnneWimsey ice cream, heart transplants, chicken parts.... none of them have to be kept at -80 like the Pfizer vaccine. This vaccine can’t be stored in your kitchen freezer, any more than sperm donation can. The Moderna vaccine can.

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