“Oh, I love your religion ... for the crazy! Virgin birth. Water into wine. It's like Harry Potter, but it causes genocide and bad folk music.”
— Roger The Alien, American Dad!, Season 6: Rapture's Delight

The thing that encourages the religious most, is being around other people who take their same nonsense equally seriously.
They become self affirming.
This is why they hate being mocked and laughed at, because at fundamental level, there is a part of their hind brain that knows, absolutely KNOWS that it is all ridiculous bullshit.
A man who can walk on water
A man whose picture can never be drawn
A woman who claimed to have a virgin birth
A god who needed to become his own father so he could torture himself to death and so forgive a mythical couple and a talking snake the sin of scrumping
An all loving god who massacred all the children of Egypt all in one night unless they had a door with a red cross on it.
And two men who flew up to heaven while still alive, one of whom was allowed to take his horse with him.

You need an awful lot of reassurance to keep on believing this crap and not fall about laughing... or a lot of fear of being stoned, burned alive or other wise persuaded to keep your giggling gob shut in from of the local psychopaths and pervert priests!

So yes, laugh, mock, knock down that wall of mutual assurance, prick the bubble of pomposity and point out that all the same stuff they take SO seriously they laugh at readily when it is someone of another "faith" claiming it for their god.

To run amok to mock what's mock?

Yes, because ultimately it may be a small pain now, for their own greater good in the future. Is it cruel to withhold food from someone suffering, perhaps fatally, from obesity, or to tell a hard truth to someone in danger from substance abuse ?

No. Live & let live.

Is it honourable? No, it's not. Is it necessary? Occasionally. We each have a moral compass that guides our choices.

“Mock them.

Ridicule them.

In public.”

Religion “needs to be ridiculed.

With contempt.” - Richard Dawkins

Yes, the damage they have inflicted on civilization and the natural planet is overwhelming.