In my case, it wasn't anything scandalous..I came out as a partial transmale without a sexual orientation (demisexual) to my siblings in 2014, as soon as I realized it, but they didn't even comment.

Then, this year, I came out as an agnostic, and one of them made a weak attempt at trying to change my mind, but since she's a liberal and doesn't even attend church, I just laughed it off.

But then three of my siblings came out as Trump supporters and I defriended/blocked them and haven't contacted them since.

I was more frightened of telling my family I was a non believer than I was if telling them I was queer. I am fortunate enough that my family are really supportive and loving. I did lose a few "friends" but I don't need those people in my life.