I'd spend it to remove CO2 and methane from the atmosphere, which requires a huge corporation and projects around the world. It would create many jobs.

The latter … though whatever amount I ‘won’ would remain a spit in the ocean compared to what my industrial political opponents could & would continue to spend.. But I’d spend it anyway

I would judiciously help, but with the understanding that it has to be done right or you're pouring money down a hole in some way. People have a tendency to ultimately resent you for bestowing largesse upon them because it subtly diminishes their own potency and effectiveness in the world, and/or makes them feel beholden to you. I would focus on causes that help people save themselves, not causes that save people. Also causes that create an environment that tends to lift people out of poverty and disease and want by providing the basics that society often fails to provide -- clean water, vaccines, healthcare services, etc.

But sure, there's no way to enrich my life beyond having a couple hundred grand a year to spend in perpetuity, which might require a few million in investments to live off the gains. Beyond that you can bet that every dime would be given away, somehow or other. I wouldn't have to be shamed into it like Jeff Bezos or something.

Im reminded of these wise words from office space: "You don't need a million dollars to do nothin [or isolate yourself] take a look at my cousin... Hes broke, don't do shit."

I would help family, friends and charitable entities. (environmental, civil rights, abuse of power etc)
For myself, a house and car in the U.S., Australia and the U.K. just because I can, ? with access to a private chef, masseuse and housekeeper. AND a private jet big enough to take all my family and friends with me when I fly to all these wonderful places. ?

Pick up my little house with construction helicopters & place it where there is a view with water.
Help family & friends
Do good with the rest....Heifer International, Smile Train, ACLU

I would only isolate for the first year or so. Just enough time to invest the money and start using it to make money.

After things got settled down, I would determine how much of the monthly interest I required to live comfortably and invest the rest in various charitable and plilanthropic causes. The principle would only be used in cases of dire emergency.

What? Where is fun in isolating? Why would anyone choose that? I don't know about helping the enlightenment. I just want to feed the kids. Hell with the enlightenment.