When we left the Mormon church my wife and I decided instead of the tithing we were paying, we would each support a single charity with regular contributions, she chose "Save the Whales" I choose "North East Air Ambulance service".
I don't think I would change if I had more to give, just a little more a little more often.

HEIFER International, ACLU & Smile Train, which I give to now, I would just up my giving.

I guess . based on my history , I give the largest and most frequent donations to Planned Parenthood .

Planned Parenthood, ACLU, anything animal

Special education-funding for special needs children
Cancer/leukemia research
Music and Drama Programs for children
Animal Rescue

I'd invest in green technologies. I'd donate to the Freedom From Religion Foundation.

I would contribute to 3 types of causes:

1. Those which protect our civil and constitutional rights.
2. Those which mount transferable programs which empower and enable people to develop and sustain themselves over time.
   3 Those which invest in developing technologies which support ecological and climate sustainability.

I would donate to the following : Population active international ,Environmental Defense Fund, Wildlife Conservation Society, P.E.T.A., Greenpeace, Sea Shepherd conservation society, Sierra Club,Rainforest Action Network , to name a few

I'd like to be in a position where I could purchase bad student loan debt (pennies on the dollar in most cases) from a collection agency, and then forgive it... just erase it. Remove it from their credit record.

I would want to contribute to a variety of causes, but right near the top would be environmental and civil rights promotion/protection. Specifically, LGBT homeless youth shelters and mentorship programs, especially in deep red states that tend not to give a shit about these abandoned kids.
Secondly, something to promote adoption of solar and wind power, including upgrading of a smart electrical grid.

Can't truthfully answer that. I don't know. I would probably hire people to do that for me as a tax write off. Yeah.... that's how you stay on top.